Micro flow cell: Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
The Raman flow assembly brings in-line Raman spectroscopy to downstream bioprocessing. Comprised of a flow cell and associated flow bench connected to an Rxn-10 probe, this system meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow assembly provides real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Midstream: analyte monitoring in permeate
Voordelen
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Achieves lower limits of detection through enhancement of the Raman signal
Provides continuous, real-time measurements with high sensitivity for development-scale flow rates
Verhoog de veiligheid in de fabriek, waarborg de productkwaliteit en optimaliseer de processen. Raman-spectroscopie meet de samenstelling en moleculaire structuur van uw monsters van lab naar proces in realtime.
Micro flow bench: Operating: 0 to 40 °C / 32 to 104 °F Storage: -10 to 50 °C / 14 to 122 °F Micro flow cell: Operating: 0 to 40 °C / 32 to 104 °F Storage: -20 to 60 °C / -4 to 140 °F
Relative humidity
Micro flow cell: Storage: < 90 % Non-Condensing
Unit dimensions (width x height x depth)
Micro flow bench: 254 x 102 x 66 mm 10.0 x 4.0 x 2.6 inch Micro flow cell: 46 x 25 x 11 mm 1.8 x 1.0 x 0.4 inch
Sampling probe compatibility
Raman Rxn-10 in tandem
Sample interface
Micro flow bench: Micro flow cell
Pressure
Micro flow cell: Max pressure: 4.8 barg / 70 psig
Wetted materials
Micro flow cell: Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
Sterilization method
Micro flow cell: CIP/SIP
Process connection
Micro flow cell: 5/16-24 flat bottom ferrules Up to 3/16 inch OD tubing
Fluid Path Thickness
Micro flow bench: 1.0 to 5.0 mm (flow cell driven) Micro flow cell: 2.5 mm
Raman flow assembly - Precise composition measurement of
high-speed, low-volume samples in downstream bioprocessing
PU (publicatie)
Engelse versie - 05/2023
New version available in English
An overview of the Raman flow assembly (flow bench and flow cell) used with the Rxn-10 probe in conjunction with a Raman Rxn2 analyzer and a Raman flow assembly calibration and verification kit for downstream bioprocessing (powered by Kaiser Raman technology).
Raman calibration and verification kits - Everything needed to
calibrate and verify your Raman analyzer system for lab-to-process
scalability
PU (publicatie)
Engelse versie - 12/2023
New version available in English
An overview of the Raman calibration and verification kits for the bio multi optic / single use optic and the Raman flow assembly (includes the flow bench and flow cell). These kits are to be used in conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer for upstream and downstream bioprocessing (powered by Kaiser Raman technology).
Raman technology in bioprocessing - Scalable in situ bioprocess
monitoring enabling advanced process control
Innovatie (IN)
Engelse versie - 06/2023
New version available in English
An overview brochure about our Raman spectroscopy analyzer and probe portfolio, powered by Kaiser Raman technology, for the bioprocessing / biopharmaceutical industry (including the Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, Rxn-45 probe, Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single use optic system, bio multi optic with bio sleeve, and Raman flow assembly), powered by Kaiser Raman technology.
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